The difficulties experienced by children with ADHD may change as they grow up; however, the challenges do not seem to diminish, social difficulties with peers may worsen, abuse of alcohol, drugs, and nicotine may emerge, and individuals may be a greater risk for involvement with the juvenile justice system. A disappointing trajectory for students with ADHD, however, is not written in stone. Protective factors for youth include: early intervention and support, strong parenting, and intensive educational support including strategies for coping and learning. While teens and adults are often more likely to stop taking medicines, studies have shown that continued use of medication as part of a multimodal approach to regulate ADHD symptoms may be helpful. To place a child with ADHD on the pathway toward a successful life it takes a concerted team effort. Early intervention, consistent and continued support for the child and family, and multimodal approaches that combine medicine, behavioral therapies, and educational interventions are needed to help children with ADHD grow into happy productive adults.